Single-Step Syntheses of 2-Amino-7-chlorothiazolo[5,4-<i>d</i>]pyrimidines:  Intermediates for Bivalent Thiazolopyrimidines Jian Liu Raymond J. Patch Carsten Schubert Mark R. Player 10.1021/jo0517702.s002 https://acs.figshare.com/articles/journal_contribution/Single_Step_Syntheses_of_2_Amino_7_chlorothiazolo_5_4_i_d_i_pyrimidines_Intermediates_for_Bivalent_Thiazolopyrimidines/3255250 A single-step process for the preparation of 2-amino-7-chlorothiazolo[5,4-<i>d</i>]pyrimidines, <b>2</b>, was achieved by the reaction of the commercially available 4,6-dichloro-5-aminopyrimidine <b>1</b> with isothiocyanates. This mild reaction accommodates a variety of functionalized isothiocyanates and proceeds in good to excellent yields. The utility of such intermediates is exemplified by subsequent reaction with alkyl or arylamine nucleophiles to afford novel, differentially functionalized 2,7-diaminothiazolo[5,4-<i>d</i>]pyrimidines, <b>3</b>. 2005-11-25 00:00:00 arylamine nucleophiles Bivalent Thiazolopyrimidines functionalized isothiocyanates