Single-Step Syntheses of
2-Amino-7-chlorothiazolo[5,4-<i>d</i>]pyrimidines:
Intermediates for Bivalent
Thiazolopyrimidines
Jian Liu
Raymond J. Patch
Carsten Schubert
Mark R. Player
10.1021/jo0517702.s002
https://acs.figshare.com/articles/journal_contribution/Single_Step_Syntheses_of_2_Amino_7_chlorothiazolo_5_4_i_d_i_pyrimidines_Intermediates_for_Bivalent_Thiazolopyrimidines/3255250
A single-step process for the preparation of 2-amino-7-chlorothiazolo[5,4-<i>d</i>]pyrimidines, <b>2</b>, was achieved by the
reaction of the commercially available 4,6-dichloro-5-aminopyrimidine <b>1</b> with isothiocyanates. This mild reaction
accommodates a variety of functionalized isothiocyanates
and proceeds in good to excellent yields. The utility of such
intermediates is exemplified by subsequent reaction with
alkyl or arylamine nucleophiles to afford novel, differentially
functionalized 2,7-diaminothiazolo[5,4-<i>d</i>]pyrimidines, <b>3</b>.
2005-11-25 00:00:00
arylamine nucleophiles
Bivalent Thiazolopyrimidines
functionalized isothiocyanates