%0 Journal Article %A Pagliai, Francesca %A Pirali, Tracey %A Grosso, Erika Del %A Brisco, Riccardo Di %A Tron, Gian Cesare %A Sorba, Giovanni %A Genazzani, Armando A. %D 2006 %T Rapid Synthesis of Triazole-Modified Resveratrol Analogues via Click Chemistry %U https://acs.figshare.com/articles/journal_contribution/Rapid_Synthesis_of_Triazole_Modified_Resveratrol_Analogues_via_Click_Chemistry/3241540 %R 10.1021/jm051118z.s001 %2 https://ndownloader.figshare.com/files/5075605 %K resveratrol %K array %K Preliminary data %K Click Chemistry Resveratrol %K Huisgen %K cycloaddition %K combinatorial approach %K derivative %K phytoalexin %K potency %K compound %K Rapid Synthesis %K triazole ring %K Analogue %K synthesis %K display %K procedure %K bond %X Resveratrol is a phytoalexin able to display an array of biological activities. We decided to replace the double bond with a triazole ring using the archetypical click reaction:  the Huisgen [3 + 2] cycloaddition. Seventy-two triazole derivatives were synthesized via a parallel combinatorial approach. Preliminary data suggest that this procedure can lead to the synthesis of compounds that display some, but not all, of resveratrol's actions with increased potency. %I ACS Publications