Rapid Synthesis of Triazole-Modified Resveratrol Analogues via Click Chemistry Francesca Pagliai Tracey Pirali Erika Del Grosso Riccardo Di Brisco Gian Cesare Tron Giovanni Sorba Armando A. Genazzani 10.1021/jm051118z.s001 https://acs.figshare.com/articles/journal_contribution/Rapid_Synthesis_of_Triazole_Modified_Resveratrol_Analogues_via_Click_Chemistry/3241540 Resveratrol is a phytoalexin able to display an array of biological activities. We decided to replace the double bond with a triazole ring using the archetypical click reaction:  the Huisgen [3 + 2] cycloaddition. Seventy-two triazole derivatives were synthesized via a parallel combinatorial approach. Preliminary data suggest that this procedure can lead to the synthesis of compounds that display some, but not all, of resveratrol's actions with increased potency. 2006-01-26 00:00:00 resveratrol array Preliminary data Click Chemistry Resveratrol Huisgen cycloaddition combinatorial approach derivative phytoalexin potency compound Rapid Synthesis triazole ring Analogue synthesis display procedure bond