Rapid Synthesis of Triazole-Modified Resveratrol
Analogues via Click Chemistry
Francesca Pagliai
Tracey Pirali
Erika Del Grosso
Riccardo Di Brisco
Gian Cesare Tron
Giovanni Sorba
Armando A. Genazzani
10.1021/jm051118z.s001
https://acs.figshare.com/articles/journal_contribution/Rapid_Synthesis_of_Triazole_Modified_Resveratrol_Analogues_via_Click_Chemistry/3241540
Resveratrol is a phytoalexin able to display an array of
biological activities. We decided to replace the double bond with a
triazole ring using the archetypical click reaction: the Huisgen [3 +
2] cycloaddition. Seventy-two triazole derivatives were synthesized via
a parallel combinatorial approach. Preliminary data suggest that this
procedure can lead to the synthesis of compounds that display some,
but not all, of resveratrol's actions with increased potency.
2006-01-26 00:00:00
resveratrol
array
Preliminary data
Click Chemistry Resveratrol
Huisgen
cycloaddition
combinatorial approach
derivative
phytoalexin
potency
compound
Rapid Synthesis
triazole ring
Analogue
synthesis
display
procedure
bond