Ren, Sheng Wang, Jun Chen, Tie-Long Li, Hao-Yu Wan, Yu-Shun Peng, Nan-Fang Gui, Xi-En Zhu, Ying A schematic figure shows the relationship between FN and HBV. <p>HBV increases FN expression through activation of Sp1. In turn, induced FN facilitates HBV replication and expression via two distinct mechanisms: 1) FN binds to the TAK-TAB complex, inhibits phosphorylation of TAK1 and reduces the nuclear translocation of NF-κB p65 to decrease endogenous IFN-α production; 2) FN activates HBV EII activity by mediating the binding of liver-specific factor HNF-4α.</p> hepatitis B Virus Stimulated Fibronectin Facilitates Viral Maintenance;Distinct Mechanisms Fibronectin;hepatitis B virus;weight extracellular matrix protein;hepatic cell lines Huh 7;IFN;protein kinase 1;HBV DNA replication;transcriptional factor specificity protein 1;NF;TAK 1 phosphorylation;FN expression;support HBV expression;HepG 2. HBV infection 2016-03-29
    https://plos.figshare.com/articles/figure/A_schematic_figure_shows_the_relationship_between_FN_and_HBV_/3152986
10.1371/journal.pone.0152721.g009