A schematic figure shows the relationship between FN and HBV. Sheng Ren Jun Wang Tie-Long Chen Hao-Yu Li Yu-Shun Wan Nan-Fang Peng Xi-En Gui Ying Zhu 10.1371/journal.pone.0152721.g009 https://plos.figshare.com/articles/figure/A_schematic_figure_shows_the_relationship_between_FN_and_HBV_/3152986 <p>HBV increases FN expression through activation of Sp1. In turn, induced FN facilitates HBV replication and expression via two distinct mechanisms: 1) FN binds to the TAK-TAB complex, inhibits phosphorylation of TAK1 and reduces the nuclear translocation of NF-κB p65 to decrease endogenous IFN-α production; 2) FN activates HBV EII activity by mediating the binding of liver-specific factor HNF-4α.</p> 2016-03-29 08:06:07 hepatitis B Virus Stimulated Fibronectin Facilitates Viral Maintenance Distinct Mechanisms Fibronectin hepatitis B virus weight extracellular matrix protein hepatic cell lines Huh 7 IFN protein kinase 1 HBV DNA replication transcriptional factor specificity protein 1 NF TAK 1 phosphorylation FN expression support HBV expression HepG 2. HBV infection