A schematic figure shows the relationship between FN and HBV.
Sheng Ren
Jun Wang
Tie-Long Chen
Hao-Yu Li
Yu-Shun Wan
Nan-Fang Peng
Xi-En Gui
Ying Zhu
10.1371/journal.pone.0152721.g009
https://plos.figshare.com/articles/figure/A_schematic_figure_shows_the_relationship_between_FN_and_HBV_/3152986
<p>HBV increases FN expression through activation of Sp1. In turn, induced FN facilitates HBV replication and expression via two distinct mechanisms: 1) FN binds to the TAK-TAB complex, inhibits phosphorylation of TAK1 and reduces the nuclear translocation of NF-κB p65 to decrease endogenous IFN-α production; 2) FN activates HBV EII activity by mediating the binding of liver-specific factor HNF-4α.</p>
2016-03-29 08:06:07
hepatitis B Virus Stimulated Fibronectin Facilitates Viral Maintenance
Distinct Mechanisms Fibronectin
hepatitis B virus
weight extracellular matrix protein
hepatic cell lines Huh 7
IFN
protein kinase 1
HBV DNA replication
transcriptional factor specificity protein 1
NF
TAK 1 phosphorylation
FN expression
support HBV expression
HepG 2. HBV infection