10.6084/m9.figshare.31441.v1 Sylvia Dörr Sylvia Dörr Nadine Lechtenböhmer Nadine Lechtenböhmer Rolf Rau Rolf Rau Gertraud Herborn Gertraud Herborn Ulf Wagner Ulf Wagner Bertram Müller-Myhsok Bertram Müller-Myhsok Ingo Hansmann Ingo Hansmann Gernot Keyszer Gernot Keyszer Three-dimensional surface plot showing the main effects for a multiple regression of total Ratingen score versus duration of disease and number of 1G()-5A() haplotypes figshare 2011 threedimensional number disease duration versus ratingen total regression multiple effects plot haplotypes 2011-12-30 22:48:07 Figure https://figshare.com/articles/figure/Three-dimensional_surface_plot_showing_the_main_effects_for_a_multiple_regression_of_total_Ratingen_score_versus_duration_of_disease_and_number_of_1G_-5A__haplotypes/31441 <p><b>Copyright information:</b></p><p>Taken from "Association of a specific haplotype across the genes and with radiographic joint destruction in rheumatoid arthritis"</p><p>Arthritis Research & Therapy 2004;6(3):R199-R207.</p><p>Published online 8 Mar 2004</p><p>PMCID:PMC416441.</p><p>Copyright © 2004 Dörr et al., licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.</p> The plot was created by distance-weighted least-squares interpolation. Black lines represent patients with either none or two 1G-5A haplotypes. The broken line, representing patients with one haplotype, is an approximation because it was not possible to determine exactly the number of patients with one 1G-5A haplotype. The arrow indicates the maximum increase in the Ratingen score after 15 years of rheumatoid arthritis in patients with no 1G-5A haplotype (see the text for further explanations). MMP, matrix metalloproteinase.