Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase To Inhibit Cancer Proliferation Shao-Lin Zhang Xiaohui Hu Wen Zhang Kin Yip Tam 10.1021/acs.jmedchem.5b01828.s002 https://acs.figshare.com/articles/dataset/Unexpected_Discovery_of_Dichloroacetate_Derived_Adenosine_Triphosphate_Competitors_Targeting_Pyruvate_Dehydrogenase_Kinase_To_Inhibit_Cancer_Proliferation/3141955 Pyruvate dehydrogenase kinases (PDKs) have recently emerged as an attractive target for cancer therapy. Herein, we prepared a series of compounds derived from dichloroacetate (DCA) which inhibited cancer cells proliferation. For the first time, we have successfully developed DCA derived inhibitors that preferentially bind to the adenosine triphosphate (ATP) pocket of PDK isoform 1 (PDK1). 2016-03-23 00:00:00 Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase cancer cells proliferation ATP DCA adenosine triphosphate Unexpected Discovery Inhibit Cancer Proliferation Pyruvate dehydrogenase kinases PDK isoform 1 cancer therapy