In vivo low dose rapamycin treatment attenuates activation-induced cell death of activated CD4+ T cells. Zili Zhang Xiumei Wu Jie Duan David Hinrichs Keith Wegmann Gary L. Zhang Mark Hall James T. Rosenbaum 10.1371/journal.pone.0036589.g007 https://plos.figshare.com/articles/figure/_In_vivo_low_dose_rapamycin_treatment_attenuates_activation_induced_cell_death_of_activated_CD4_T_cells_/314188 <p>B10.RIII mice were treated with or without daily rapamycin (1.5 µg/mouse) as described previously. On day 21, the spleens were harvested, and further cultured in the presence or absence of anti-CD3 antibody (10 µg/ml) and anti-CD28 antibody (2 µg/ml). Seventy two hours later, the apoptosis of activated CD4+CD44+ T cells was analyzed by flow cytometry for Annexin V staining (All the data represent the mean of 6 animals per group; * p<0.05).</p> 2013-02-20 05:38:43 vivo rapamycin attenuates activation-induced activated