%0 Journal Article %A Li, Yu-Peng %A Zhao, Si-Meng %A Xu, Jun-Ju %A Zeng, Guang-Zhi %A Li, Yan %A Tan, Ning-Hua %A Yang, Ye %D 2016 %T New Labdane diterpenes from Hedychium yunnanense with cytotoxicity and inhibitory effects on nitric oxide production %U https://tandf.figshare.com/articles/journal_contribution/New_Labdane_diterpenes_from_i_Hedychium_yunnanense_i_with_cytotoxicity_and_inhibitory_effects_on_nitric_oxide_production/3103123 %R 10.6084/m9.figshare.3103123.v1 %2 https://ndownloader.figshare.com/files/4824058 %K Zingiberaceae %K Hedychium yunnanense %K labdane diterpenes %K inhibition of NO production %K cytotoxicity %X

Two new labdane diterpenes, hedychenoids A (1) and B (2), were isolated from the rhizomes of Hedychium yunnanense, together with four known ones hedychenone (3), forrestin A (4), villosin (5) and calcaratarin C (6). Their structures were determined on the basis of NMR (1D and 2D) and mass spectroscopic analysis. Compounds 2, 3 and 5 exhibited cytotoxicity against SGC-7901 with IC50 values of 14.88 ± 0.52, 7.08 ± 0.21 and 7.76 ± 0.21 μg/ml, 3 and 5 against HeLa with IC50 values of 9.76 ± 0.48 and 13.24 ± 0.63 μg/ml, respectively. Compounds 2, 5 showed inhibitory effects against nitric oxide production in LPS and IFN-γ-induced RAW 264.7 murine macrophages with IC50 values of 6.57 ± 0.88 and 5.99 ± 1.20 μg/ml, respectively.

%I Taylor & Francis