%0 Journal Article %A García-Fortanet, Jorge %A Murga, Juan %A Carda, Miguel %A Marco, J. Alberto %D 2006 %T Stereoselective Synthesis of the Cytotoxic Macrolide FD-891 %U https://acs.figshare.com/articles/journal_contribution/Stereoselective_Synthesis_of_the_Cytotoxic_Macrolide_FD_891_sup_sup_/3074788 %R 10.1021/ol060669w.s004 %2 https://ndownloader.figshare.com/files/4780567 %K stereoselectively %K FD %K Stereoselective Synthesis %K olefination %K allylation reactions %K synthesis %K Cytotoxic %K fragment %K Macrolide %K framework %K cytotoxic %K Yamaguchi reaction %K macrolactone ring %K macrolide %K Julia %K aldol %X A total synthesis of the naturally occurring, cytotoxic macrolide FD-891 is described. Three fragments were first stereoselectively constructed using mainly asymmetric aldol and allylation reactions. The complete framework was then assembled using two Julia−Kocienski olefinations to connect the three fragments and a Yamaguchi reaction to close the macrolactone ring. %I ACS Publications