10.1021/bc060060f.s001
Michel Wathier
Michel
Wathier
C. Starck Johnson
C. Starck
Johnson
Terry Kim
Terry
Kim
Mark W. Grinstaff
Mark W.
Grinstaff
Hydrogels Formed by Multiple Peptide Ligation Reactions To Fasten Corneal
Transplants
American Chemical Society
2006
terminal ester aldehydes
hydrogel
pseudoproline peptide ligation chemistry
Fasten Corneal TransplantsA
Multiple Peptide Ligation Reactions
PEG macromolecule
2006-07-19 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Hydrogels_Formed_by_Multiple_Peptide_Ligation_Reactions_To_Fasten_Corneal_Transplants/3070066
A stable cross-linked hydrogel was formed under mild aqueous conditions using pseudoproline peptide ligation
chemistry. A cysteine-terminated lysine dendron containing four cysteines and a PEG macromolecule modified
with terminal ester aldehydes were prepared. Upon mixing, the two macromers gave a stable hydrogel. This
hydrogel along with sutures was used to successfully secure a corneal transplant in vitro.