10.1021/ol061451c.s001 Jeffrey D. Winkler Jeffrey D. Winkler Sylvie M. Asselin Sylvie M. Asselin Synthesis of Novel Heterocyclic Structures via Reaction of Isocyanides with <i>S-trans</i>-Enones American Chemical Society 2006 pyrrole i.e zwitterionic cyclization NR Synthesi Novel Heterocyclic Structures Isocyanide equivalent formation furan enone nucleophilic moiety isocyanide 2006-08-31 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Novel_Heterocyclic_Structures_via_Reaction_of_Isocyanides_with_i_S_trans_i_Enones/3062368 The reaction of enone <b>1</b>, bearing an internal nucleophilic moiety, i.e., furan or pyrrole (X = O, NR‘), with isocyanides is presented. The formation of products resulting from the reaction of the zwitterionic intermediate <b>2</b> with a second equivalent of isocyanide prior to cyclization to give <b>3</b>, as well as the direct formation of <b>4</b> from <b>2</b>, is described.