Efficient Microwave-Assisted Synthesis of Amine-Substituted Tetrakis(pentafluorophenyl)porphyrin Diana Samaroo Clifford E. Soll Louis J. Todaro Charles M. Drain 10.1021/ol060946z.s002 https://acs.figshare.com/articles/journal_contribution/Efficient_Microwave_Assisted_Synthesis_of_Amine_Substituted_Tetrakis_pentafluorophenyl_porphyrin/3051613 We report an efficient and rapid means for the synthesis of tetrakis(pentafluorophenyl)porphyrin (TPPF<sub>20</sub>) derivatives by microwave irradiation in an environmentally acceptable solvent. The selective displacement of the <i>para</i>-fluorine groups in TPPF<sub>20</sub> by primary amines occurs in yields between 70 and 95%. This method demonstrates that TPPF<sub>20</sub> is an ideal platform for the rapid formation of porphyrin conjugates for therapeutic, catalytic, and other applications. 2006-10-26 00:00:00 Tetraki Efficient displacement TPPF 20 tetraki application platform derivative method synthesis amines formation microwave irradiation yield porphyrin conjugates Synthesi