Efficient Microwave-Assisted Synthesis
of Amine-Substituted
Tetrakis(pentafluorophenyl)porphyrin
Diana Samaroo
Clifford E. Soll
Louis J. Todaro
Charles M. Drain
10.1021/ol060946z.s002
https://acs.figshare.com/articles/journal_contribution/Efficient_Microwave_Assisted_Synthesis_of_Amine_Substituted_Tetrakis_pentafluorophenyl_porphyrin/3051613
We report an efficient and rapid means for the synthesis of tetrakis(pentafluorophenyl)porphyrin (TPPF<sub>20</sub>) derivatives by microwave irradiation
in an environmentally acceptable solvent. The selective displacement of the <i>para</i>-fluorine groups in TPPF<sub>20</sub> by primary amines occurs in yields
between 70 and 95%. This method demonstrates that TPPF<sub>20</sub> is an ideal platform for the rapid formation of porphyrin conjugates for therapeutic,
catalytic, and other applications.
2006-10-26 00:00:00
Tetraki
Efficient
displacement
TPPF 20
tetraki
application
platform
derivative
method
synthesis
amines
formation
microwave irradiation
yield
porphyrin conjugates
Synthesi