10.1021/jp066811s.s001
V. Zoulalian
V.
Zoulalian
S. Monge
S.
Monge
S. Zürcher
S.
Zürcher
M. Textor
M.
Textor
J. J. Robin
J. J.
Robin
S. Tosatti
S.
Tosatti
Functionalization of Titanium Oxide Surfaces by Means of Poly(alkyl-phosphonates)
American Chemical Society
2006
stability
attachment sites strategy
XPS
PEG side chains
methacrylate
angle spectroscopic ellipsometry
titanium oxide surfaces
Titanium Oxide Surfaces
pH
serum
adlayer
exposure
protein adsorption
monomer
2006-12-28 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Functionalization_of_Titanium_Oxide_Surfaces_by_Means_of_Poly_alkyl_phosphonates_/3037564
The use of a multiple attachment sites strategy is considered in order to improve the stability of monomolecular
adlayers. The hypothesis was tested in the case of PEG-ylated compounds carrying phosphonate groups,
known for their affinity toward titanium oxide surfaces. As a result, a new class of co- and terpolymers were
synthesized by free-radical polymerization of three different monomers: dialkyl(methacryloyloxyalkyl)phosphonates, PEG methyl ether methacrylate, and/or butyl methacrylate monomers. Adlayers were formed
following a simple dip-and-rinse protocol using diluted aqueous polymer solutions and were characterized by
evaluating their thicknesses with variable angle spectroscopic ellipsometry (VASE) and their elemental
compositions with X-ray photoelectron spectroscopy (XPS). The same techniques were used to determine
changes of the adlayer as a function of exposure to electrolytes at different pH values and to monitor nonspecific
protein adsorption upon serum exposures. The results indicated that the poly(alkyl-phosphonate)-based adlayers
combine multiple site attachment of phosphonic groups and presentation of PEG side chains to the aqueous
environment, resulting in both improved stability over a wide pH range in comparison to the tested reference
surfaces and excellent resistance to protein adsorption when exposed to full human serum.