%0 Journal Article
%A Ahmed, Sahar
%A Beleid, Reem
%A Sprules, Tara
%A Kaur, Kamaljit
%D 2007
%T Solid-Phase Synthesis and CD
Spectroscopic Investigations of Novel
β-Peptides from l-Aspartic Acid and
β-Amino-l-alanine
%U https://acs.figshare.com/articles/journal_contribution/Solid_Phase_Synthesis_and_CD_Spectroscopic_Investigations_of_Novel_Peptides_from_l_Aspartic_Acid_and_Amino_l_alanine/3034618
%R 10.1021/ol062465l.s001
%2 https://ndownloader.figshare.com/files/4737259
%K sequential side chain substitutions
%K solution conformation
%K hexapeptide
%K representative peptides
%K CD Spectroscopic Investigations
%X A solid-phase synthesis method for the preparation of novel β3- and β2-peptides derived from l-aspartic acid and β-amino-l-alanine, respectively,
is described. The methodology allows independent buildup of the β-peptide backbone and the introduction of sequential side chain substitutions.
Representative peptides from the two classes, an amino-substituted β3-hexapeptide and an acyl-substituted β2-hexapeptide, have been prepared,
and their solution conformation is studied by circular dichroism (CD) spectroscopy.
%I ACS Publications