%0 Journal Article %A Ahmed, Sahar %A Beleid, Reem %A Sprules, Tara %A Kaur, Kamaljit %D 2007 %T Solid-Phase Synthesis and CD Spectroscopic Investigations of Novel β-Peptides from l-Aspartic Acid and β-Amino-l-alanine %U https://acs.figshare.com/articles/journal_contribution/Solid_Phase_Synthesis_and_CD_Spectroscopic_Investigations_of_Novel_Peptides_from_l_Aspartic_Acid_and_Amino_l_alanine/3034618 %R 10.1021/ol062465l.s001 %2 https://ndownloader.figshare.com/files/4737259 %K sequential side chain substitutions %K solution conformation %K hexapeptide %K representative peptides %K CD Spectroscopic Investigations %X A solid-phase synthesis method for the preparation of novel β3- and β2-peptides derived from l-aspartic acid and β-amino-l-alanine, respectively, is described. The methodology allows independent buildup of the β-peptide backbone and the introduction of sequential side chain substitutions. Representative peptides from the two classes, an amino-substituted β3-hexapeptide and an acyl-substituted β2-hexapeptide, have been prepared, and their solution conformation is studied by circular dichroism (CD) spectroscopy. %I ACS Publications