TY - DATA T1 - Synthesis of the Oxygenated Pactamycin Core PY - 2007/03/29 AU - Spencer Knapp AU - Younong Yu UR - https://acs.figshare.com/articles/dataset/Synthesis_of_the_Oxygenated_Pactamycin_Core/3016510 DO - 10.1021/ol0702472.s001 L4 - https://ndownloader.figshare.com/files/4717822 KW - functionalized aminocyclitol antibiotics KW - steric KW - core carbons KW - group compatibility KW - reactivity KW - stereochemistry KW - type KW - Synthesi KW - polyfunctionalized KW - cyclopentane KW - protection KW - functionalization reactions KW - oxygenated functionality KW - approach KW - challenge KW - Oxygenated Pactamycin CorePactamycin N2 - Pactamycin, one of the most complex and densely functionalized aminocyclitol antibiotics known, presents synthetic challenges that include reactivity and sterics, relative and absolute stereochemistry, and functional group compatibility and protection. An approach is reported that features four different types of (cyclopentane) face selective functionalization reactions and results in a polyfunctionalized and appropriately protected intermediate that incorporates all the core carbons and the oxygenated functionality of the target. ER -