%0 Figure %A M. Abdelmagid, Samir %A E. Barr, Ann %A Rico, Mario %A Amin, Mamta %A Litvin, Judith %A N. Popoff, Steven %A F. Safadi, Fayez %A F. Barbe, Mary %D 2013 %T Increased CTGF and collagen staining decreases after anti-inflammatory drug treatments. %U https://plos.figshare.com/articles/figure/_Increased_CTGF_and_collagen_staining_decreases_after_anti_inflammatory_drug_treatments_/301061 %R 10.1371/journal.pone.0038359.g006 %2 https://ndownloader.figshare.com/files/630577 %K ctgf %K collagen %K staining %K decreases %K anti-inflammatory %X

CTGF immunohistochemistry (panels A–F) and Masson's trichrome staining (panels G,H) increased in flexor digitorum muscles (M) and lumbricals in TR-HF and 6-week HRHF task rats, and decrease with anti-inflammatory drugs. Panels A–F show CTGF immunostaining (red) of flexor digitorum muscles from: (A) TR-HF, (B) TR-HF treated with anti-TNF-α, (C) untreated 6-week HRHF (showing CTGF-immunostained cells at edges of myofibers), (D) 6-week HRHF treated with anti-TNF-α (inset shows small CTGF-immunostained cells in endomyseum), (E) 6-week HRHF treated with ibuprofen, and (F) untreated 6-week HRHF (showing increased CTGF-immunostained cells in endomyseum (ct)). (G) Quantification of percent area with CTGF immunostaining. **p<0.01 compared to NC; ## p<0.01 compared to TR-HF; &&p<0.01 compared to untreated 6-week HRHF; n = 4–12/gp. (F) Lumbricals from Region B stained with Masson's Trichrome showing: (H) increased blue stained collagen matrix in an untreated 6-week HRHF rat, and (I) decreased blue staining in a 6-week HRHF treated with anti-TNF-α. Scale bars = 50 µm.

%I PLOS ONE