Mapes, Christopher M. Mani, Neelakandha S. High-Yielding Syntheses of 1-Piperidin-4-yl Butyro- and Valerolactams through a Tandem Reductive Amination−Lactamization (Reductive Lactamization) We report a procedure for the concise and high-yielding syntheses of 1-piperidin-4-yl-substituted butyro- and valerolactams. Beginning with 1-benzyl-4-piperidone and γ- or δ-amino esters or acids, we have effected a tandem reductive amination−lactamization using sodium triacetoxyborohydride. This procedure represents an inexpensive and scaleable alternative to previous multistep syntheses of these important pharmaceutical building blocks. esters;scaleable alternative;Synthese;Reductive Lactamization;acid;Valerolactam;building blocks;Piperidin;Butyro;Tandem;reductive;valerolactam;piperidin;benzyl;Amination;butyro;amination;tandem;sodium triacetoxyborohydride;multistep syntheses;procedure 2007-05-18
    https://acs.figshare.com/articles/journal_contribution/High_Yielding_Syntheses_of_1_Piperidin_4_yl_Butyro_and_Valerolactams_through_a_Tandem_Reductive_Amination_Lactamization_Reductive_Lactamization_/3006340
10.1021/op700016b.s002