Loss of CLPTM1L sensitizes lung tumor cells to genotoxic agents.
Michael A. James
Weidong Wen
Yian Wang
Lauren A. Byers
John V. Heymach
Kevin R. Coombes
Luc Girard
John Minna
Ming You
10.1371/journal.pone.0036116.g002
https://plos.figshare.com/articles/figure/_Loss_of_CLPTM1L_sensitizes_lung_tumor_cells_to_genotoxic_agents_/299156
<p>A) Knockdown of CLPTM1L expression in A549 cells via stable shRNA. Confirmation of knockdown by western blot (inset). B) Knockdown of CLPTM1L expression in H838 cells via stable shRNA. Confirmation of knockdown by western blot (inset). C) Relative cell viability of A549 cells with CLPTM1L knockdown after 48 hours treatment with media or cisplatin. D) Relative cell viability of H838 cells with CLPTM1L knockdown after 48 hours treatment with DMSO vehicle or 1<b> </b>µM camptothecin. E) Relative cell viability of H1299 cells with CLPTM1L over-expression after 48 hours treatment with DMSO vehicle or 10<b> </b>µM camptothecin. Error bars represent one standard deviation from the mean of biological triplicates.</p>
2012-06-04 02:32:36
clptm1l
sensitizes
cells
genotoxic