%0 Journal Article
%A Miranda, Oscar R.
%A You, Chang-Cheng
%A Phillips, Ronnie
%A Kim, Ik-Bum
%A Ghosh, Partha S.
%A H. F. Bunz, Uwe
%A Rotello, Vincent M.
%D 2007
%T Array-Based Sensing of Proteins Using Conjugated Polymers
%U https://acs.figshare.com/articles/journal_contribution/Array_Based_Sensing_of_Proteins_Using_Conjugated_Polymers/2991490
%R 10.1021/ja0737927.s001
%2 https://ndownloader.figshare.com/files/4692364
%K polymer
%K protein analytes
%K 17 proteins
%K fluorescence properties
%K identification accuracy
%K Conjugated PolymersA sensor array
%K fluorescence response pattern
%K protein samples
%K Linear discriminant analyses
%K micromolar concentrations
%X A sensor array comprising six functionalized poly(p-phenyleneethynylene) polymers was constructed and used to detect and identify protein analytes. The presence of proteins alters the fluorescence properties of the polymers, generating a distinct fluorescence response pattern for a given protein. Linear discriminant analyses accurately differentiate the patterns of 17 proteins at nano- to micromolar concentrations. An identification accuracy of 97% was obtained on the basis of the tests with 68 unknown protein samples from the training set.
%I ACS Publications