Li, Xin Kyne, Robert E. Ovaska, Timo V. Synthesis of Seven-Membered Carbocyclic Rings via a Microwave-Assisted Tandem Oxyanionic 5-<i>exo</i> <i>dig</i> Cyclization−Claisen Rearrangement Process Appropriately substituted 1-alkenyl-4-pentyn-1-ol systems, readily prepared from simple starting materials, serve as useful precursors to a number of substituted cyclohept-4-enone derivatives via a microwave-assisted tandem oxyanionic 5-<i>exo</i> cyclization/Claisen rearrangement sequence. The reactions involving terminally substituted 4-pentyn-1-ols were found to be highly stereoselective, with the α and β groups in the final product showing a strong preference for the <i>trans</i> orientation. trans orientation;stereoselective;Cyclization;cyclohept;Oxyanionic;sequence;cyclization;Tandem;derivative;ProcessAppropriately;Synthesi;oxyanionic;pentyn;material;tandem;preference;Carbocyclic;Rearrangement;alkenyl;precursor;exo;β groups;rearrangement;terminally 2007-08-17
    https://acs.figshare.com/articles/journal_contribution/Synthesis_of_Seven_Membered_Carbocyclic_Rings_via_a_Microwave_Assisted_Tandem_Oxyanionic_5_i_exo_i_i_dig_i_Cyclization_Claisen_Rearrangement_Process/2990632
10.1021/jo0710432.s004