Efficient Post-Macrocyclization
Functionalizations of
Oxacalix[2]arene[2]pyrimidines
Wim Van Rossom
Wouter Maes
Lingam Kishore
Margriet Ovaere
Luc Van Meervelt
Wim Dehaen
10.1021/ol702864y.s003
https://acs.figshare.com/articles/dataset/Efficient_Post_Macrocyclization_Functionalizations_of_Oxacalix_2_arene_2_pyrimidines/2956078
Diversely functionalized oxacalix[2]arene[2]pyrimidines have been synthesized starting from a bis(methylsulfanyl)-substituted oxacalix[4]arene
by two efficient post-macrocyclization pathways. Functionalized aryl groups were introduced on the pyrimidine building block via Liebeskind−Srogl cross-coupling reactions, while a variety of O-, S-, N-, and C-nucleophiles were inserted on the calixarene skeleton by nucleophilic
aromatic substitution reactions on the bis(methylsulfonyl)oxacalix[4]arene analogue.
2008-02-21 00:00:00
functionalized
Efficient
nucleophilic
Functionalization
calixarene skeleton
variety
pyrimidine building block
analogue
Liebeskind
substitution reactions
bi
Oxacalix
Diversely
oxacalix
pathway
Functionalized aryl groups