Efficient Post-Macrocyclization Functionalizations of Oxacalix[2]arene[2]pyrimidines Wim Van Rossom Wouter Maes Lingam Kishore Margriet Ovaere Luc Van Meervelt Wim Dehaen 10.1021/ol702864y.s003 https://acs.figshare.com/articles/dataset/Efficient_Post_Macrocyclization_Functionalizations_of_Oxacalix_2_arene_2_pyrimidines/2956078 Diversely functionalized oxacalix[2]arene[2]pyrimidines have been synthesized starting from a bis(methylsulfanyl)-substituted oxacalix[4]arene by two efficient post-macrocyclization pathways. Functionalized aryl groups were introduced on the pyrimidine building block via Liebeskind−Srogl cross-coupling reactions, while a variety of O-, S-, N-, and C-nucleophiles were inserted on the calixarene skeleton by nucleophilic aromatic substitution reactions on the bis(methylsulfonyl)oxacalix[4]arene analogue. 2008-02-21 00:00:00 functionalized Efficient nucleophilic Functionalization calixarene skeleton variety pyrimidine building block analogue Liebeskind substitution reactions bi Oxacalix Diversely oxacalix pathway Functionalized aryl groups