Gribble, Michael W. Ellman, Jonathan A. Bergman, Robert G. Synthesis of a Benzodiazepine-Derived Rhodium NHC Complex by C−H Bond Activation The synthesis and characterization of a Rh(I)−NHC complex generated by C−H activation of a 1,4-benzodiazepine heterocycle are reported. This complex constitutes a rare example of a carbene tautomer of a 1,4-benzodiazepine aldimine stabilized by transition metal coordination and demonstrates the ability of the catalytically relevant RhCl(PCy<sub>3</sub>)<sub>2</sub> fragment to induce NHC-forming tautomerization of heterocycles possessing a single carbene-stabilizing heteroatom. Implications for the synthesis of benzodiazepines and related pharmacophores via C−H functionalization are discussed. characterization;Complex;transition metal coordination;Rh;Rhodium;NHC;benzodiazepine;pharmacophore;carbene tautomer;aldimine;ActivationThe;functionalization;synthesis;ability;heterocycle;benzodiazepines;fragment;activation;heteroatom;tautomerization;Implication;catalytically;Bond;RhCl;Synthesi 2008-05-26
    https://acs.figshare.com/articles/journal_contribution/Synthesis_of_a_Benzodiazepine_Derived_Rhodium_NHC_Complex_by_C_H_Bond_Activation/2937382
10.1021/om8000839.s001