10.1021/jo801150e.s001
Marco Santarem
Marco
Santarem
Corinne Vanucci-Bacqué
Corinne
Vanucci-Bacqué
Gérard Lhommet
Gérard
Lhommet
Formal Total Synthesis of (+)-Gephyrotoxin
American Chemical Society
2008
enamino
Gephyrotoxin
synthesis
pyrrolidine
strategy
ester
Formal
gephyrotoxin
diastereoselective reduction
condensation
chiral
Synthesi
hydroxy
2008-08-15 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Formal_Total_Synthesis_of_Gephyrotoxin/2920900
An efficient formal total synthesis of (+)-gephyrotoxin is described. The key step of our strategy relies on the diastereoselective reduction of a chiral pyrrolidine β-enamino ester obtained by condensation of (<i>S</i>)-phenylglycinol on a protected 8-hydroxy-3,6-dioxooctanoate.