10.1021/jo801150e.s001 Marco Santarem Marco Santarem Corinne Vanucci-Bacqué Corinne Vanucci-Bacqué Gérard Lhommet Gérard Lhommet Formal Total Synthesis of (+)-Gephyrotoxin American Chemical Society 2008 enamino Gephyrotoxin synthesis pyrrolidine strategy ester Formal gephyrotoxin diastereoselective reduction condensation chiral Synthesi hydroxy 2008-08-15 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Formal_Total_Synthesis_of_Gephyrotoxin/2920900 An efficient formal total synthesis of (+)-gephyrotoxin is described. The key step of our strategy relies on the diastereoselective reduction of a chiral pyrrolidine β-enamino ester obtained by condensation of (<i>S</i>)-phenylglycinol on a protected 8-hydroxy-3,6-dioxooctanoate.