Zhang, Zhenqing Weïwer, Michel Li, Boyangzi Kemp, Melissa M. Daman, Tyler H. Linhardt, Robert J. Oversulfated Chondroitin Sulfate: Impact of a Heparin Impurity, Associated with Adverse Clinical Events, on Low-Molecular-Weight Heparin Preparation Heparin, a widely used anticoagulant, is being rapidly displaced by low-molecular-weight heparins. Recently, certain lots of heparin have been associated with anaphylactoid-type reactions resulting from contamination with oversulfated chondroitin sulfate. This impurity has also contaminated low-molecular-weight heparins obtained by chemical and enzymatic depolymerization of heparin. The sensitivity of oversulfated chondroitin sulfate to five different depolymerization processes similar to ones used in preparing low-molecular-weight heparins is reported. Adverse Clinical Events;Heparin Impurity;depolymerization processes;oversulfated chondroitin sulfate;heparin;Oversulfated Chondroitin Sulfate 2008-09-25
    https://acs.figshare.com/articles/journal_contribution/Oversulfated_Chondroitin_Sulfate_Impact_of_a_Heparin_Impurity_Associated_with_Adverse_Clinical_Events_on_Low_Molecular_Weight_Heparin_Preparation/2911678
10.1021/jm800785t.s001