Mont, Nuria Mehta, Vaibhav Pravinchandra Appukkuttan, Prasad Beryozkina, Tetyana Toppet, Suzzane Hecke, Kristof Van Meervelt, Luc Van Voet, Arnout DeMaeyer, Marc Van der Eycken, Erik Diversity Oriented Microwave-Assisted Synthesis of (−)-Steganacin Aza-Analogues A novel microwave-assisted, highly efficient protocol for the synthesis of <i>hitherto</i> unknown aza-analogues of (−)-Steganacin, a naturally occurring bisbenzocyclooctadiene lignan lactone with potent antileukemic and tubulin polymerization inhibitory activity, has been developed. Focused microwave irradiation is demonstrated to be highly beneficial in promoting the three crucial steps of the sequence to effect the final ring closure: the Suzuki−Miyaura reaction, Cu-mediated A<sub>3</sub>-coupling, as well as the intramolecular Huisgen 1,3-dipolar cycloaddition. bisbenzocyclooctadiene lignan lactone;sequence;Oriented;intramolecular;Suzuki;Diversity;Focused microwave irradiation;Huisgen;cycloaddition;ring closure;synthesis;dipolar;Steganacin;tubulin polymerization;Synthesi;antileukemic 2008-10-03
    https://acs.figshare.com/articles/dataset/Diversity_Oriented_Microwave_Assisted_Synthesis_of_Steganacin_Aza_Analogues/2909776
10.1021/jo801290j.s002