10.1021/jo801290j.s002
Nuria Mont
Nuria
Mont
Vaibhav Pravinchandra Mehta
Vaibhav Pravinchandra
Mehta
Prasad Appukkuttan
Prasad
Appukkuttan
Tetyana Beryozkina
Tetyana
Beryozkina
Suzzane Toppet
Suzzane
Toppet
Kristof Van Hecke
Kristof Van
Hecke
Luc Van Meervelt
Luc Van
Meervelt
Arnout Voet
Arnout
Voet
Marc DeMaeyer
Marc
DeMaeyer
Erik Van der Eycken
Erik
Van der Eycken
Diversity Oriented Microwave-Assisted Synthesis of (−)-Steganacin Aza-Analogues
American Chemical Society
2008
bisbenzocyclooctadiene lignan lactone
sequence
Oriented
intramolecular
Suzuki
Diversity
Focused microwave irradiation
Huisgen
cycloaddition
ring closure
synthesis
dipolar
Steganacin
tubulin polymerization
Synthesi
antileukemic
2008-10-03 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Diversity_Oriented_Microwave_Assisted_Synthesis_of_Steganacin_Aza_Analogues/2909776
A novel microwave-assisted, highly efficient protocol for the synthesis of <i>hitherto</i> unknown aza-analogues of (−)-Steganacin, a naturally occurring bisbenzocyclooctadiene lignan lactone with potent antileukemic and tubulin polymerization inhibitory activity, has been developed. Focused microwave irradiation is demonstrated to be highly beneficial in promoting the three crucial steps of the sequence to effect the final ring closure: the Suzuki−Miyaura reaction, Cu-mediated A<sub>3</sub>-coupling, as well as the intramolecular Huisgen 1,3-dipolar cycloaddition.