10.1021/jo801290j.s002 Nuria Mont Nuria Mont Vaibhav Pravinchandra Mehta Vaibhav Pravinchandra Mehta Prasad Appukkuttan Prasad Appukkuttan Tetyana Beryozkina Tetyana Beryozkina Suzzane Toppet Suzzane Toppet Kristof Van Hecke Kristof Van Hecke Luc Van Meervelt Luc Van Meervelt Arnout Voet Arnout Voet Marc DeMaeyer Marc DeMaeyer Erik Van der Eycken Erik Van der Eycken Diversity Oriented Microwave-Assisted Synthesis of (−)-Steganacin Aza-Analogues American Chemical Society 2008 bisbenzocyclooctadiene lignan lactone sequence Oriented intramolecular Suzuki Diversity Focused microwave irradiation Huisgen cycloaddition ring closure synthesis dipolar Steganacin tubulin polymerization Synthesi antileukemic 2008-10-03 00:00:00 Dataset https://acs.figshare.com/articles/dataset/Diversity_Oriented_Microwave_Assisted_Synthesis_of_Steganacin_Aza_Analogues/2909776 A novel microwave-assisted, highly efficient protocol for the synthesis of <i>hitherto</i> unknown aza-analogues of (−)-Steganacin, a naturally occurring bisbenzocyclooctadiene lignan lactone with potent antileukemic and tubulin polymerization inhibitory activity, has been developed. Focused microwave irradiation is demonstrated to be highly beneficial in promoting the three crucial steps of the sequence to effect the final ring closure: the Suzuki−Miyaura reaction, Cu-mediated A<sub>3</sub>-coupling, as well as the intramolecular Huisgen 1,3-dipolar cycloaddition.