TY - DATA T1 - Enantioselective Total Synthesis of (+)-Cassiol PY - 2009/01/15 AU - Krastina V. Petrova AU - Justin T. Mohr AU - Brian M. Stoltz UR - https://acs.figshare.com/articles/journal_contribution/Enantioselective_Total_Synthesis_of_Cassiol/2885437 DO - 10.1021/ol802410t.s001 L4 - https://ndownloader.figshare.com/files/4583350 KW - Enantioselective KW - sequence KW - enantioconvergent KW - convergent KW - catalyze KW - Pd KW - strategy KW - enantioselective KW - ligand KW - quaternary carbon stereocenter KW - decarboxylative KW - Cassiol KW - alkylation KW - fragment KW - synthesis features KW - cassiol KW - enantiopure KW - Synthesi N2 - An enantioselective total synthesis of (+)-cassiol is reported. The complex derived from Pd2(pmdba)3 and enantiopure t-BuPHOX ligand catalyzes enantioconvergent decarboxylative alkylation to generate the quaternary carbon stereocenter at an early stage. The overall synthetic strategy involves a convergent late-stage coupling of two fragments. The synthesis features a longest linear sequence of eight steps. ER -