TY - DATA T1 - Enantioselective Sequential Conjugate Addition−Allylation Reactions: A Concise Total Synthesis of (+)-Podophyllotoxin PY - 2009/02/05 AU - Yingming Wu AU - Jingfeng Zhao AU - Jingbo Chen AU - Chengxue Pan AU - Liang Li AU - Hongbin Zhang UR - https://acs.figshare.com/articles/journal_contribution/Enantioselective_Sequential_Conjugate_Addition_Allylation_Reactions_A_Concise_Total_Synthesis_of_Podophyllotoxin/2880763 DO - 10.1021/ol8026208.s002 L4 - https://ndownloader.figshare.com/files/4578658 KW - Enantioselective KW - Sequential KW - conjugate KW - acid KW - enantioselective KW - sequential KW - synthesis KW - Podophyllotoxin KW - trimethoxycinnamic KW - Concise KW - podophyllotoxin KW - Conjugate KW - Synthesi N2 - A highly flexible and concise total synthesis of (+)-podophyllotoxin featured with an enantioselective sequential conjugate addition-allylation reaction was reported. Starting from commercially available 3,4,5-trimethoxycinnamic acid, this new route leads to (+)-podophyllotoxin 1 in only eight steps with 29% overall yield. ER -