Hydrophilic Modifications of an Amphiphilic Polynorbornene and the Effects on its Hemolytic and Antibacterial Activity
Semra Colak
Christopher F. Nelson
Klaus Nüsslein
Gregory N. Tew
10.1021/bm801129y.s001
https://acs.figshare.com/articles/journal_contribution/Hydrophilic_Modifications_of_an_Amphiphilic_Polynorbornene_and_the_Effects_on_its_Hemolytic_and_Antibacterial_Activity/2879662
Here we report the modification of an amphiphilic antibacterial polynorbornene, <b>Poly3</b>, via incorporation of hydrophilic, biocompatible groups. The sugar, zwitterionic, and polyethylene glycol based moieties were incorporated in varying ratios by copolymerization and postpolymerization techniques. Well-defined copolymers with molecular weights of 3 kDa and narrow polydispersity indices ranging from 1.08 to 1.15 were obtained. The effects of these modifications on the biological activity of these polymers were analyzed by determining their minimum inhibitory concentrations (MIC) and their hemolytic activities (HC<sub>50</sub>).
2009-02-09 00:00:00
moietie
MIC
Amphiphilic Polynorbornene
HC
concentration
copolymerization
1.15
zwitterionic
biocompatible groups
postpolymerization techniques
copolymers
Antibacterial ActivityHere
modification
polydispersity indices
polynorbornene
polyethylene glycol
incorporation
Hydrophilic Modifications
ratio
3 kDa
1.08
amphiphilic
Hemolytic