Hydrophilic Modifications of an Amphiphilic Polynorbornene and the Effects on its Hemolytic and Antibacterial Activity Semra Colak Christopher F. Nelson Klaus Nüsslein Gregory N. Tew 10.1021/bm801129y.s001 https://acs.figshare.com/articles/journal_contribution/Hydrophilic_Modifications_of_an_Amphiphilic_Polynorbornene_and_the_Effects_on_its_Hemolytic_and_Antibacterial_Activity/2879662 Here we report the modification of an amphiphilic antibacterial polynorbornene, <b>Poly3</b>, via incorporation of hydrophilic, biocompatible groups. The sugar, zwitterionic, and polyethylene glycol based moieties were incorporated in varying ratios by copolymerization and postpolymerization techniques. Well-defined copolymers with molecular weights of 3 kDa and narrow polydispersity indices ranging from 1.08 to 1.15 were obtained. The effects of these modifications on the biological activity of these polymers were analyzed by determining their minimum inhibitory concentrations (MIC) and their hemolytic activities (HC<sub>50</sub>). 2009-02-09 00:00:00 moietie MIC Amphiphilic Polynorbornene HC concentration copolymerization 1.15 zwitterionic biocompatible groups postpolymerization techniques copolymers Antibacterial ActivityHere modification polydispersity indices polynorbornene polyethylene glycol incorporation Hydrophilic Modifications ratio 3 kDa 1.08 amphiphilic Hemolytic