Identification of 3-Acetyl-2-aminoquinolin-4-one as a Novel, Nonpeptidic Scaffold for Specific Calpain Inhibitory Activity Da-Hye Kang Kyu-Yeon Jun Jin Pyo Lee Chwang Siek Pak Younghwa Na Youngjoo Kwon 10.1021/jm8014734.s001 https://acs.figshare.com/articles/journal_contribution/Identification_of_3_Acetyl_2_aminoquinolin_4_one_as_a_Novel_Nonpeptidic_Scaffold_for_Specific_Calpain_Inhibitory_Activity/2857135 A series of 3-acetyl-2-aminoquinolin-4-one derivatives selected from the Korean Chemical Bank were screened for calpain inhibitory activity by using a high-throughput fluorimetric calpain assay. We identified a potent and selective μ-calpain inhibitor, compound <b>17</b>, whose specificity and efficacy for μ-calpain inhibition was better than MDL28170. Docking studies revealed that the efficacy of its inhibitory effect on calpain depended on the size and charge properties of the substitutions on the phenylamino ring. 2009-05-14 00:00:00 Nonpeptidic Scaffold charge properties efficacy MDL 28170. Docking studies Korean Chemical Bank phenylamino ring calpain Specific Calpain Inhibitory ActivityA series