%0 Journal Article %A Lee, Ho Yong %A Jiang, Xuan %A Lee, Dongwhan %D 2009 %T Kinetics of Self-Immolation: Faster Signal Relay over a Longer Linear Distance? %U https://acs.figshare.com/articles/journal_contribution/Kinetics_of_Self_Immolation_Faster_Signal_Relay_over_a_Longer_Linear_Distance_/2855497 %R 10.1021/ol900433g.s001 %2 https://ndownloader.figshare.com/files/4553242 %K bias %K transduction %K shortcut %K Linear Distance %K pathway %K Signal Relay %K counterintuitive observation %K quinone methide rearrangements %K elimination %K Kinetic %K signal %X A counterintuitive observation of a faster signal relay over a longer linear distance prompted detailed kinetic studies of self-immolation reactions. With appropriate conformational bias, trigger-to-reporter signal transduction can take an efficient “shortcut” that outperforms conventional pathways involving repetitive quinone methide rearrangements and elimination. %I ACS Publications