In<i></i> Vitro and In<i></i> Vivo Nonlinear Optical Imaging of Silicon Nanowires
Yookyung Jung
Ling Tong
Asama Tanaudommongkon
Ji-Xin Cheng
Chen Yang
10.1021/nl901143p.s003
https://acs.figshare.com/articles/media/In_i_i_Vitro_and_In_i_i_Vivo_Nonlinear_Optical_Imaging_of_Silicon_Nanowires/2851180
Understanding of cellular interactions with a nanostructure requires tracking directly the nanostructure. Current investigation is challenged by the lack of a strong, intrinsic signal from the nanostructure. We demonstrate intensive four-wave mixing and third-harmonic generation signals from dimension-controllable silicon nanowires as small as 5 nm in diameter. The nonlinear optical signals observed from the nanowires are highly photostable with an intensity level of 10 times larger than that observed from silver nanoparticles of comparable sizes. This intrinsic optical signal enabled intravital imaging of nanowires circulating in the peripheral blood of a mouse and mapping of nanowires accumulated in the liver and spleen, opening up further opportunities to investigate in<i></i> vivo cellular response to nanomaterials as a function of size, aspect ratio, and surface chemistry.
2009-06-10 00:00:00
Current investigation
aspect ratio
Silicon NanowiresUnderstanding
intensity level
silver nanoparticles
10 times
Vivo Nonlinear Optical Imaging
nanowire
surface chemistry
5 nm
signal
intravital imaging
nanostructure