Hyaluronic Acid−Quantum Dot Conjugates for <i>In Vivo</i> Lymphatic Vessel Imaging Suk Ho Bhang Nayoun Won Tae-Jin Lee Ho Jin Jutaek Nam Joonhyuck Park Hyokyun Chung Hyun-Seo Park Yung-Eun Sung Sei Kwang Hahn Byung-Soo Kim Sungjee Kim 10.1021/nn900138d.s001 https://acs.figshare.com/articles/media/Hyaluronic_Acid_Quantum_Dot_Conjugates_for_i_In_Vivo_i_Lymphatic_Vessel_Imaging/2848417 A simple and novel electrostatic coupling method is reported, which provides a hyaluronic acid−quantum dot conjugate (HA−QD) that is colloidally stable and size-tunable from 50 to 120 nm. The HA−QDs show cancer targeting efficiency, which suggests diagnostic and imaging applications. The conjugates are also demonstrated for the fluorescence staining capability for lymphatic vessels <i>in vitro</i> and <i>in vivo</i>. Using the HA−QDs in a small animal model, lymphatic vessels are visualized real-time <i>in vivo</i> for days. Comprehensive cytotoxicity evaluations are made for the conjugates and the unconjugated counterpart. The HA−QDs showcase the potentials toward cancer imaging and real-time visualization of changes in lymphatic vessels such as lymphangiogenesis. 2009-06-23 00:00:00 fluorescence staining capability vivo conjugate HA Vivo Lymphatic Vessel ImagingA Comprehensive cytotoxicity evaluations lymphatic vessels imaging