Conformational Effects in Diastereoselective Aryne Diels−Alder Reactions: Synthesis of Benzo-Fused [2.2.1] Heterobicycles Robert Webster Mark Lautens 10.1021/ol9019869.s012 https://acs.figshare.com/articles/dataset/Conformational_Effects_in_Diastereoselective_Aryne_Diels_Alder_Reactions_Synthesis_of_Benzo_Fused_2_2_1_Heterobicycles/2821366 It was found that the diastereoselectivity of the Diels−Alder reaction between arynes and substituted furans is highly sensitive to substitution, which affects the reactive conformation. By varying the location of the groups on the diene partner, it is possible to obtain both excellent chemical yields and high stereoselectivity. This methodology offers rapid and convenient access to enantiomerically pure bicyclic scaffolds which are difficult to prepare by other means. 2009-10-15 00:00:00 bicyclic scaffolds furan diastereoselectivity Aryne enantiomerically chemical yields aryne methodology location Diel Heterobicycle Synthesi Conformational Effects stereoselectivity substitution Diastereoselective diene partner access reactive conformation