10.1021/jm901262f.s001 Claudia Cardinaletti Claudia Cardinaletti Laura Mattioli Laura Mattioli Francesca Ghelfi Francesca Ghelfi Fabio Del Bello Fabio Del Bello Mario Giannella Mario Giannella Ariana Bruzzone Ariana Bruzzone Hervé Paris Hervé Paris Marina Perfumi Marina Perfumi Alessandro Piergentili Alessandro Piergentili Wilma Quaglia Wilma Quaglia Maria Pigini Maria Pigini Might Adrenergic α<sub>2C</sub>-Agonists/α<sub>2A</sub>-Antagonists Become Novel Therapeutic Tools for Pain Treatment with Morphine? American Chemical Society 2009 oxyethylene bridge steric bulk Novel Therapeutic Tools morphine analgesia modulation adjuvant agents Pain Treatment ortho substituent phenyl ring position 2 α2 AR 2009-11-26 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Might_Adrenergic_sub_2C_sub_Agonists_sub_2A_sub_Antagonists_Become_Novel_Therapeutic_Tools_for_Pain_Treatment_with_Morphine_/2810173 The imidazoline nucleus linked in position 2 via an oxyethylene bridge to a phenyl ring carrying an ortho substituent of moderate steric bulk provided α<sub>2</sub>-adrenergic (AR) ligands endowed with significant α<sub>2C</sub>-agonism/α<sub>2A</sub>-antagonism. Similar behavior was displayed by cirazoline (<b>12</b>). For their positive morphine analgesia modulation (due to α<sub>2C</sub>-AR stimulation) and sedation overcoming (due to α<sub>2A</sub>-AR antagonism), <b>8</b> and <b>11</b> might be useful as adjuvant agents in the management of pain with morphine.