Singh, A. Jonathan Xu, Chun-Xiao Xu, Xiaoming West, Lyndon M. Wilmes, Anja Chan, Ariane Hamel, Ernest Miller, John H. Northcote, Peter T. Ghosh, Arun K. Peloruside B, A Potent Antitumor Macrolide from the New Zealand Marine Sponge Mycale hentscheli: Isolation, Structure, Total Synthesis, and Bioactivity Peloruside B (<b>2</b>), a natural congener of peloruside A (<b>1</b>), was isolated in sub-milligram quantities from the New Zealand marine sponge Mycale hentscheli. Peloruside B promotes microtubule polymerization and arrests cells in the G<sub>2</sub>/M phase of mitosis similar to paclitaxel, and its bioactivity was comparable to that of peloruside A. NMR-directed isolation, structure elucidation, structure confirmation by total synthesis, and bioactivity of peloruside B are described in this article. The synthesis features Sharpless dihydroxylation, Brown’s asymmetric allylboration reaction, reductive aldol coupling, Yamaguchi macrolactonization, and selective methylation. Peloruside B;New Zealand Marine Sponge Mycale hentscheli;New Zealand marine sponge Mycale hentscheli;peloruside;Potent Antitumor Macrolide;synthesis features Sharpless dihydroxylation;bioactivity 2010-01-01
    https://acs.figshare.com/articles/journal_contribution/Peloruside_B_A_Potent_Antitumor_Macrolide_from_the_New_Zealand_Marine_Sponge_Mycale_hentscheli_Isolation_Structure_Total_Synthesis_and_Bioactivity/2803003
10.1021/jo9021265.s002