Cobalt(II)-Catalyzed Intermolecular Benzylic C−H Amination with 2,2,2-Trichloroethoxycarbonyl Azide (TrocN<sub>3</sub>)
Hongjian Lu
Velusamy Subbarayan
Jingran Tao
X. Peter Zhang
10.1021/om900916g.s001
https://acs.figshare.com/articles/journal_contribution/Cobalt_II_Catalyzed_Intermolecular_Benzylic_C_H_Amination_with_2_2_2_Trichloroethoxycarbonyl_Azide_TrocN_sub_3_sub_/2797660
2,2,2-Trichloroethoxycarbonyl azide (TrocN<sub>3</sub>) is an effective nitrene source for cobalt(II)-catalyzed intermolecular nitrene insertion of C−H bonds. Among different metalloporphyrins studied, Co(II)(TPP) was shown to be a competent catalyst for the selective amination of various benzylic C−H bonds under mild conditions without the need of other reagents or additives, forming the desired Troc-protected amines in moderate to high yields with nitrogen gas as the only byproduct.
2010-01-25 00:00:00
Azide
nitrene source
cobalt
metalloporphyrin
additive
azide
Trichloroethoxycarbonyl
Amination
nitrogen gas
byproduct
Benzylic
amines
reagent
nitrene insertion
catalyst
TrocN
benzylic
Co
yield
Cobalt
amination
Intermolecular
bond