Targeted Cytosolic Delivery of Cell-Impermeable Compounds by Nanoparticle-Mediated, Light-Triggered Endosome Disruption
SeĢbastien Febvay
Davide M. Marini
Angela M. Belcher
David E. Clapham
10.1021/nl101157z.s002
https://acs.figshare.com/articles/media/Targeted_Cytosolic_Delivery_of_Cell_Impermeable_Compounds_by_Nanoparticle_Mediated_Light_Triggered_Endosome_Disruption/2762731
Nanoparticle (NP)-mediated drug delivery typically relies on cargo release to occur passively or in response to environmental stimuli. Here we present a delivery method based on light-activated disruption of intracellular vesicles after internalization of biofunctionalized mesoporous silica nanoparticles loaded with cargo. This method combines the power of targeted delivery with the spatiotemporal control of light activation. As an example, we delivered a cell-impermeable fluorescent compound exclusively to the cytosol of multidrug resistant cancer cells in a mixed population.
2010-06-09 00:00:00
cancer cells
delivery method
intracellular vesicles
spatiotemporal control
NP
cargo release
light activation
biofunctionalized mesoporous silica nanoparticles
Targeted Cytosolic Delivery