Targeted Cytosolic Delivery of Cell-Impermeable Compounds by Nanoparticle-Mediated, Light-Triggered Endosome Disruption SeĢbastien Febvay Davide M. Marini Angela M. Belcher David E. Clapham 10.1021/nl101157z.s002 https://acs.figshare.com/articles/media/Targeted_Cytosolic_Delivery_of_Cell_Impermeable_Compounds_by_Nanoparticle_Mediated_Light_Triggered_Endosome_Disruption/2762731 Nanoparticle (NP)-mediated drug delivery typically relies on cargo release to occur passively or in response to environmental stimuli. Here we present a delivery method based on light-activated disruption of intracellular vesicles after internalization of biofunctionalized mesoporous silica nanoparticles loaded with cargo. This method combines the power of targeted delivery with the spatiotemporal control of light activation. As an example, we delivered a cell-impermeable fluorescent compound exclusively to the cytosol of multidrug resistant cancer cells in a mixed population. 2010-06-09 00:00:00 cancer cells delivery method intracellular vesicles spatiotemporal control NP cargo release light activation biofunctionalized mesoporous silica nanoparticles Targeted Cytosolic Delivery