10.1021/ac101495m.s001 Meikun Fan Meikun Fan Matthew Thompson Matthew Thompson Maria Luiza Andrade Maria Luiza Andrade Alexandre G. Brolo Alexandre G. Brolo Silver Nanoparticles on a Plastic Platform for Localized Surface Plasmon Resonance Biosensing American Chemical Society 2010 surface plasmon resonance SNOPS strip sensor strips Localized Surface Plasmon Resonance BiosensingA protein adsorption Ag NPs Silver Nanoparticles 500 nM LSPR biosensor Plastic Platform fabrication method polyethylene terephthalate 2010-08-01 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Silver_Nanoparticles_on_a_Plastic_Platform_for_Localized_Surface_Plasmon_Resonance_Biosensing/2747467 A cost-effective fabrication method for the preparation of localized surface plasmon resonance (LSPR) biosensors supported on plastics is described. The silver-nanoparticles-on-plastic sensor (SNOPS) was fabricated by chemically modifying the surface of a common plastic, polyethylene terephthalate (PET) to allow the efficient immobilization of Ag NPs. The LSPR of the SNOPS strip showed good sample-to-sample reproducibility. The analytical performance of the sensor strips for monitoring both thiol and protein adsorption, including bioaffinity, was examined. The limit of quantification to the adsorption of 11-mercaptoundecanoic acid was 500 nM and for the detection of streptavidin was ∼9.5 nM. SNOPS can then be used as a cheap, versatile, and yet sensitive LSPR biosensor.