TY - DATA T1 - Jujuboside B increased intracellular Ca2+ by inducing extracellular Ca2+ to inflow through TRPC channels. PY - 2016/02/22 AU - Yixiu Zhao AU - Xin Zhang AU - Jiannan Li AU - Yu Bian AU - Miaomiao Sheng AU - Bin Liu AU - Zidong Fu AU - Yan Zhang AU - Baofeng Yang UR - https://plos.figshare.com/articles/figure/Jujuboside_B_increased_intracellular_Ca_sup_2_sup_by_inducing_extracellular_Ca_sup_2_sup_to_inflow_through_TRPC_channels_/2733658 DO - 10.1371/journal.pone.0149386.g007 L4 - https://ndownloader.figshare.com/files/6777801 KW - rat thoracic aorta rings KW - L-NAME KW - HAEC KW - Griess reagent method KW - rat thoracic aorta ring KW - Activating Endothelial Nitric Oxide Synthase Jujuboside B KW - nitric oxide synthase KW - Jujuboside B KW - DAMP KW - Wire myograph system KW - TRPC KW - EGTA KW - KN KW - attenuated Jujuboside B-induced vasodilation KW - SKF 96365. KW - Jujuboside B-induced vasodilation KW - tension KW - laser confocal imaging microscopy N2 - (A) Representative confocal image showed that Jujuboside B induced a rapid intracellular Ca2+ elevation in HAECs instantaneously. (B) Fluorescence intensity curves showed that Jujuboside B increased intracellular Ca2+ concentration in a dose-dependent manner, n = 4. (C) Analysis of intracellular Ca2+ concentration showed that Jujuboside B increased intracellular Ca2+ concentration in a dose-dependent manner, n = 4. (D) Representative confocal image showed that EGTA inhibited Jujuboside B-induced intracellular Ca2+ increase. (E) Fluorescence intensity curves showed that EGTA significantly inhibited Jujuboside B-induced intracellular Ca2+ increase, n = 4. (F) Analysis of intracellular Ca2+ concentration showed that EGTA significantly inhibited Jujuboside B-induced intracellular Ca2+ increase, ** P < 0.01, n = 4. (G) Representative confocal image showed that SKF96365 inhibited Jujuboside B-induced intracellular Ca2+ increase. (H) Fluorescence intensity curves showed that SKF96365 significantly inhibited Jujuboside B-induced intracellular Ca2+ increase, n = 4. (I) Analysis of intracellular Ca2+ concentration showed that SKF96365 significantly inhibited Jujuboside B-induced intracellular Ca2+ increase, ** P < 0.01, n = 4. ER -