Jujuboside B increased intracellular Ca<sup>2+</sup> by inducing extracellular Ca<sup>2+</sup> to inflow through TRPC channels.
Yixiu Zhao
Xin Zhang
Jiannan Li
Yu Bian
Miaomiao Sheng
Bin Liu
Zidong Fu
Yan Zhang
Baofeng Yang
10.1371/journal.pone.0149386.g007
https://plos.figshare.com/articles/figure/Jujuboside_B_increased_intracellular_Ca_sup_2_sup_by_inducing_extracellular_Ca_sup_2_sup_to_inflow_through_TRPC_channels_/2733658
<p>(A) Representative confocal image showed that Jujuboside B induced a rapid intracellular Ca<sup>2+</sup> elevation in HAECs instantaneously. (B) Fluorescence intensity curves showed that Jujuboside B increased intracellular Ca<sup>2+</sup> concentration in a dose-dependent manner, n = 4. (C) Analysis of intracellular Ca<sup>2+</sup> concentration showed that Jujuboside B increased intracellular Ca<sup>2+</sup> concentration in a dose-dependent manner, n = 4. (D) Representative confocal image showed that EGTA inhibited Jujuboside B-induced intracellular Ca<sup>2+</sup> increase. (E) Fluorescence intensity curves showed that EGTA significantly inhibited Jujuboside B-induced intracellular Ca<sup>2+</sup> increase, n = 4. (F) Analysis of intracellular Ca<sup>2+</sup> concentration showed that EGTA significantly inhibited Jujuboside B-induced intracellular Ca<sup>2+</sup> increase, ** <i>P</i> < 0.01, n = 4. (G) Representative confocal image showed that SKF96365 inhibited Jujuboside B-induced intracellular Ca<sup>2+</sup> increase. (H) Fluorescence intensity curves showed that SKF96365 significantly inhibited Jujuboside B-induced intracellular Ca<sup>2+</sup> increase, n = 4. (I) Analysis of intracellular Ca<sup>2+</sup> concentration showed that SKF96365 significantly inhibited Jujuboside B-induced intracellular Ca<sup>2+</sup> increase, ** <i>P</i> < 0.01, n = 4.</p>
2016-02-22 09:42:27
rat thoracic aorta rings
L-NAME
HAEC
Griess reagent method
rat thoracic aorta ring
Activating Endothelial Nitric Oxide Synthase Jujuboside B
nitric oxide synthase
Jujuboside B
DAMP
Wire myograph system
TRPC
EGTA
KN
attenuated Jujuboside B-induced vasodilation
SKF 96365.
Jujuboside B-induced vasodilation
tension
laser confocal imaging microscopy