Merging Nucleophilic and Hydrogen Bonding Catalysis: An Anion Binding Approach to the Kinetic Resolution of Propargylic Amines Eric G. Klauber Chandra Kanta De Tejas K. Shah Daniel Seidel 10.1021/ja105337h.s002 https://acs.figshare.com/articles/dataset/Merging_Nucleophilic_and_Hydrogen_Bonding_Catalysis_An_Anion_Binding_Approach_to_the_Kinetic_Resolution_of_Propargylic_Amines/2724094 An efficient kinetic resolution of primary propargylic amines with s-factors of up to 56 is reported. The strategy is based on a dual catalytic approach, namely the use of a newly developed and easy-to-make thiourea-amide anion binding catalyst in combination with 4-(dimethylamino)pyridine (DMAP), both employed at a 5 mol % catalyst loading. Benzylic amines are also resolved with s-factors of up to 38. 2010-10-06 00:00:00 dimethylamino binding Kinetic Resolution loading Merging Nucleophilic strategy approach combination Anion Binding Approach 38. mol Propargylic AminesAn Benzylic amines anion DMAP propargylic amines Hydrogen Bonding Catalysis catalyst