%0 Journal Article %A Marcus, Andrew P. %A Sarpong, Richmond %D 2010 %T Synthesis of the Tetracyclic Core of Tetrapetalone A Enabled by a Pyrrole Reductive Alkyation %U https://acs.figshare.com/articles/journal_contribution/Synthesis_of_the_Tetracyclic_Core_of_Tetrapetalone_A_Enabled_by_a_Pyrrole_Reductive_Alkyation/2721784 %R 10.1021/ol1018536.s001 %2 https://ndownloader.figshare.com/files/4397746 %K Pyrrole Reductive Alkyation %K tetracyclic framework %K reductive pyrrole alkylation %K synthesis %K Tetracyclic Core %K molecule %K Enabled %K formation %K Tetrapetalone %K tetramic acid portion %K boronic ester conjugate addition %K aglycon %K tetrasubstituted carbon stereocenter %K silicon %K tetrapetalone %K Synthesi %X The tetracyclic framework of the tetrapetalone A aglycon has been secured through synthesis. A reductive pyrrole alkylation enables the formation of a key tetrasubstituted carbon stereocenter, and the tetramic acid portion of the molecule can be accessed through silicon or boronic ester conjugate addition to an ene-lactam. %I ACS Publications