Chiral Diene as the Ligand for the Synthesis of Axially Chiral Compounds via Palladium-Catalyzed Suzuki−Miyaura Coupling Reaction
Shu-Sheng Zhang
Zhi-Qian Wang
Ming-Hua Xu
Guo-Qiang Lin
10.1021/ol102521q.s001
https://acs.figshare.com/articles/journal_contribution/Chiral_Diene_as_the_Ligand_for_the_Synthesis_of_Axially_Chiral_Compounds_via_Palladium_Catalyzed_Suzuki_Miyaura_Coupling_Reaction/2707972
The first palladium−diene-catalyzed asymmetric Suzuki−Miyaura coupling reaction has been achieved. A number of functionalized biaryls were obtained in high yields and in moderate to high enantioselectivities. The existence of an <i>ortho</i>-formyl group greatly improves the catalyst efficiency and permits further synthetic elaborations.
2010-12-03 00:00:00
Chiral Diene
Axially Chiral Compounds
Suzuki
Ligand
functionalized biaryls
catalyst efficiency
Synthesi
elaboration
palladium
yield
enantioselectivitie