%0 Journal Article
%A Rachakatla, Raja Shekar
%A Balivada, Sivasai
%A Seo, Gwi-Moon
%A Myers, Carl B.
%A Wang, Hongwang
%A Samarakoon, Thilani N.
%A Dani, Raj
%A Pyle, Marla
%A Kroh, Franklin O.
%A Walker, Brandon
%A Leaym, Xiaoxuan
%A Koper, Olga B.
%A Chikan, Viktor
%A Bossmann, Stefan H.
%A Tamura, Masaaki
%A Troyer, Deryl L.
%D 2010
%T Attenuation of Mouse Melanoma by A/C Magnetic Field after Delivery of Bi-Magnetic Nanoparticles by Neural Progenitor Cells
%U https://acs.figshare.com/articles/journal_contribution/Attenuation_of_Mouse_Melanoma_by_A_C_Magnetic_Field_after_Delivery_of_Bi_Magnetic_Nanoparticles_by_Neural_Progenitor_Cells/2702131
%R 10.1021/nn100870z.s001
%2 https://ndownloader.figshare.com/files/4378078
%K cell delivery vehicles
%K AMF
%K MNP
%K melanoma
%K progenitor cells
%K NPC
%K tumor
%K Neural Progenitor CellsLocalized
%X Localized magnetic hyperthermia as a treatment modality for cancer has generated renewed interest, particularly if it can be targeted to the tumor site. We examined whether tumor-tropic neural progenitor cells (NPCs) could be utilized as cell delivery vehicles for achieving preferential accumulation of core/shell iron/iron oxide magnetic nanoparticles (MNPs) within a mouse model of melanoma. We developed aminosiloxane−porphyrin functionalized MNPs, evaluated cell viability and loading efficiency, and transplanted neural progenitor cells loaded with this cargo into mice with melanoma. NPCs were efficiently loaded with core/shell Fe/Fe3O4 MNPs with minimal cytotoxicity; the MNPs accumulated as aggregates in the cytosol. The NPCs loaded with MNPs could travel to subcutaneous melanomas, and after A/C (alternating current) magnetic field (AMF) exposure, the targeted delivery of MNPs by the cells resulted in a measurable regression of the tumors. The tumor attenuation was significant (p < 0.05) a short time (24 h) after the last of three AMF exposures.
%I ACS Publications