%0 Journal Article %A Rachakatla, Raja Shekar %A Balivada, Sivasai %A Seo, Gwi-Moon %A Myers, Carl B. %A Wang, Hongwang %A Samarakoon, Thilani N. %A Dani, Raj %A Pyle, Marla %A Kroh, Franklin O. %A Walker, Brandon %A Leaym, Xiaoxuan %A Koper, Olga B. %A Chikan, Viktor %A Bossmann, Stefan H. %A Tamura, Masaaki %A Troyer, Deryl L. %D 2010 %T Attenuation of Mouse Melanoma by A/C Magnetic Field after Delivery of Bi-Magnetic Nanoparticles by Neural Progenitor Cells %U https://acs.figshare.com/articles/journal_contribution/Attenuation_of_Mouse_Melanoma_by_A_C_Magnetic_Field_after_Delivery_of_Bi_Magnetic_Nanoparticles_by_Neural_Progenitor_Cells/2702131 %R 10.1021/nn100870z.s001 %2 https://ndownloader.figshare.com/files/4378078 %K cell delivery vehicles %K AMF %K MNP %K melanoma %K progenitor cells %K NPC %K tumor %K Neural Progenitor CellsLocalized %X Localized magnetic hyperthermia as a treatment modality for cancer has generated renewed interest, particularly if it can be targeted to the tumor site. We examined whether tumor-tropic neural progenitor cells (NPCs) could be utilized as cell delivery vehicles for achieving preferential accumulation of core/shell iron/iron oxide magnetic nanoparticles (MNPs) within a mouse model of melanoma. We developed aminosiloxane−porphyrin functionalized MNPs, evaluated cell viability and loading efficiency, and transplanted neural progenitor cells loaded with this cargo into mice with melanoma. NPCs were efficiently loaded with core/shell Fe/Fe3O4 MNPs with minimal cytotoxicity; the MNPs accumulated as aggregates in the cytosol. The NPCs loaded with MNPs could travel to subcutaneous melanomas, and after A/C (alternating current) magnetic field (AMF) exposure, the targeted delivery of MNPs by the cells resulted in a measurable regression of the tumors. The tumor attenuation was significant (p < 0.05) a short time (24 h) after the last of three AMF exposures. %I ACS Publications