%0 Generic %A Eccles, Kevin S. %A Deasy, Rebecca E. %A Fábián, László %A Maguire, Anita R. %A Lawrence, Simon E. %D 2011 %T The Use of Co-crystals for the Determination of Absolute Stereochemistry: An Alternative to Salt Formation %U https://acs.figshare.com/articles/dataset/The_Use_of_Co_crystals_for_the_Determination_of_Absolute_Stereochemistry_An_Alternative_to_Salt_Formation/2690677 %R 10.1021/jo102148p.s006 %2 https://ndownloader.figshare.com/files/4366621 %K series %K acid %K Salt FormationAbsolute stereochemistry %K HPLC conditions %K chiral HPLC %K Determination %K salt formation %K arylbutanoic %K combination %K material %K solution %K difficulty %K meaning %K compound %K diffraction %K Absolute Stereochemistry %K Alternative %X Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals. %I ACS Publications