The Use of Co-crystals for the Determination of Absolute Stereochemistry: An Alternative to Salt Formation
Kevin S. Eccles
Rebecca E. Deasy
László Fábián
Anita R. Maguire
Simon E. Lawrence
10.1021/jo102148p.s008
https://acs.figshare.com/articles/dataset/The_Use_of_Co_crystals_for_the_Determination_of_Absolute_Stereochemistry_An_Alternative_to_Salt_Formation/2690671
Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.
2011-02-18 00:00:00
series
acid
Salt FormationAbsolute stereochemistry
HPLC conditions
chiral HPLC
Determination
salt formation
arylbutanoic
combination
material
solution
difficulty
meaning
compound
diffraction
Absolute Stereochemistry
Alternative