Germain, Andrew R. Bruggemeyer, Daniel M. Zhu, Jianglong Genet, Cedric O’Brien, Peter Porco, John A. Synthesis of the Azaphilones (+)-Sclerotiorin and (+)-8-<i>O</i>-Methylsclerotiorinamine Utilizing (+)-Sparteine Surrogates in Copper-Mediated Oxidative Dearomatization Enantioselective syntheses of the azaphilone natural products (+)-sclerotiorin and (+)-8-<i>O</i>-methylsclerotiorinamine that possess the natural <i>R</i>-configuration at the quaternary center are reported. The syntheses were accomplished using copper-mediated asymmetric dearomatization employing bis-μ-oxo copper complexes prepared from readily available (+)-sparteine surrogates. Of note, site-selective <i>O</i>-methylation of a vinylogous pyridone was used to access the isoquinolin-6(7<i>H</i>)-one core of (+)-8-<i>O</i>-methylsclerotiorinamine. vinylogous pyridone;Azaphilone;dearomatization;Utilizing;quaternary center;azaphilone;complex;DearomatizationEnantioselective;Sparteine;Sclerotiorin;Synthesi;core;Surrogate;bi;Oxidative;synthese;sparteine;sclerotiorin;isoquinolin;surrogate;access 2011-04-15
    https://acs.figshare.com/articles/journal_contribution/Synthesis_of_the_Azaphilones_Sclerotiorin_and_8_i_O_i_Methylsclerotiorinamine_Utilizing_Sparteine_Surrogates_in_Copper_Mediated_Oxidative_Dearomatization/2662819
10.1021/jo102448n.s001