10.1021/pr200024m.s004
Athanasios K. Anagnostopoulos
Athanasios K.
Anagnostopoulos
Konstantinos S. Dimas
Konstantinos S.
Dimas
Chrissa Papathanassiou
Chrissa
Papathanassiou
Maria Braoudaki
Maria
Braoudaki
Ema Anastasiadou
Ema
Anastasiadou
Konstantinos Vougas
Konstantinos
Vougas
Kalliopi Karamolegou
Kalliopi
Karamolegou
Harry Kontos
Harry
Kontos
Neofytos Prodromou
Neofytos
Prodromou
Fotini Tzortzatou-Stathopoulou
Fotini
Tzortzatou-Stathopoulou
George Th. Tsangaris
George Th.
Tsangaris
Proteomics Studies of Childhood Pilocytic Astrocytoma
American Chemical Society
2011
protein profiles
brain tumors
childhood pilocytic astrocytoma occurrence
Proteomics Studies
Proteomics analysis
Childhood Pilocytic AstrocytomaChildhood pilocytic astrocytoma
brain tumor
brain tissues
ERK
evaluation
bioinformatics approaches
proteomic data
cancer research
tissue samples
proteome content
protein expression
MAPK pathway
genomic hybridization arrays
bioinformatics database construction
novel findings
2011-05-06 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Proteomics_Studies_of_Childhood_Pilocytic_Astrocytoma/2656495
Childhood pilocytic astrocytoma is the most frequent brain tumor affecting children. Proteomics analysis is currently considered a powerful tool for global evaluation of protein expression and has been widely applied in the field of cancer research. In the present study, a series of proteomics, genomics, and bioinformatics approaches were employed to identify, classify and characterize the proteome content of low-grade brain tumors as it appears in early childhood. Through bioinformatics database construction, protein profiles generated from pathological tissue samples were compared against profiles of normal brain tissues. Additionally, experiments of comparative genomic hybridization arrays were employed to monitor for genetic aberrations and sustain the interpretation and evaluation of the proteomic data. The current study confirms the dominance of MAPK pathway for the childhood pilocytic astrocytoma occurrence and novel findings regarding the ERK-2 expression are reported.